解剖学和形态学
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牙科,口腔外科和医学
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卫生保健科学和服务
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心理学,临床
abstract::In this issue of Blood, Nagai et al provide evidence that adult T-cell leukemia is hierarchically organized and sustained by a small population of transformed T memory stem cells. ...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-04-640631
更新日期:2015-06-04 00:00:00
abstract::Graft-versus-host disease (GVHD) is driven by extensive activation and proliferation of alloreactive donor T cells causing significant morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both human...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-11-612762
更新日期:2015-05-28 00:00:00
abstract::In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL. ...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-04-636332
更新日期:2015-05-28 00:00:00
abstract::Ticagrelor is a direct-acting reversibly binding P2Y12 antagonist and is widely used as an antiplatelet therapy for the prevention of cardiovascular events in acute coronary syndrome patients. However, antiplatelet therapy can be associated with an increased risk of bleeding. Here, we present data on the identificatio...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2015-01-622928
更新日期:2015-05-28 00:00:00
abstract::The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revo...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2015-01-621110
更新日期:2015-05-28 00:00:00
abstract::Members of the B7 family have been shown to be important for regulating immune responses by providing either positive or negative costimulatory signals. The function of B7-H3 has been controversial. We show that B7-H3 is upregulated in graft-versus-host disease (GVHD) target organs, including the colon, liver, and lun...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-09-603357
更新日期:2015-05-21 00:00:00
abstract::ADAMTS13 metalloprotease cleaves von Willebrand factor (VWF), thereby inhibiting platelet aggregation and arterial thrombosis. An inability to cleave ultralarge VWF resulting from hereditary or acquired deficiency of plasma ADAMTS13 activity leads to a potentially fatal syndrome, thrombotic thrombocytopenic purpura (T...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-07-587139
更新日期:2015-05-21 00:00:00
abstract::Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted parallel transcriptional...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2015-01-621631
更新日期:2015-05-14 00:00:00
abstract::Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated by the rapid development of resistance or activation of bypass pathways. For the pu...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-12-615906
更新日期:2015-05-14 00:00:00
abstract::Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the role o...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-09-601187
更新日期:2015-05-07 00:00:00
abstract::Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, their exact contribution to a mounting immune response, as well as the mechanisms and timing of their in vivo generation, are poorly understood. We longitudinally tracked TSCM dynamics in patients undergoing haploidentica...
journal_title:Blood
pub_type: 临床试验,杂志文章
doi:10.1182/blood-2014-11-608539
更新日期:2015-04-30 00:00:00
abstract::Obinutuzumab is a type 2, glycoengineered, anti-CD20 antibody recently approved with chlorambucil for the initial therapy of chronic lymphocytic leukemia (CLL). In this nonrandomized, parallel-cohort, phase 1b, multicenter study, we explored the safety and preliminary efficacy of obinutuzumab-bendamustine (G-B) or obi...
journal_title:Blood
pub_type: 杂志文章,多中心研究
doi:10.1182/blood-2014-12-613570
更新日期:2015-04-30 00:00:00
abstract::Inhibitors of bromodomain and extraterminal motif proteins (BETs) are being evaluated for the treatment of cancer and other diseases, yet much remains to be learned about how BET proteins function during normal physiology. We used genomic and genetic approaches to examine BET function in a hematopoietic maturation sys...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-10-607309
更新日期:2015-04-30 00:00:00
abstract::Oncogenic activation of NOTCH1 signaling plays a central role in the pathogenesis of T-cell acute lymphoblastic leukemia, with mutations on this signaling pathway affecting more than 60% of patients at diagnosis. However, the transcriptional regulatory circuitries driving T-cell transformation downstream of NOTCH1 rem...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-10-608448
更新日期:2015-04-30 00:00:00
abstract::Ras-associated autoimmune leukoproliferative disorder (RALD) is a chronic, nonmalignant condition that presents with persistent monocytosis and is often associated with leukocytosis, lymphoproliferation, and autoimmune phenomena. RALD has clinical and laboratory features that overlap with those of juvenile myelomonocy...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2014-11-567917
更新日期:2015-04-30 00:00:00
abstract::Cutaneous T-cell lymphomas (CTCLs) primarily affect skin and are characterized by proliferation of mature CD4(+) T-helper cells. The pattern of cytokine production in the skin and blood is considered to be of major importance for the pathogenesis of CTCLs. Abnormal cytokine expression in CTCLs may be responsible for e...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-07-590398
更新日期:2015-04-30 00:00:00
abstract::In this issue of Blood, in a first-rate example of collaboration between academia (University of California) and industry (Sangamo), Hoban et al show in situ gene correction of sickle cell anemia (SCA), a prototypical hemoglobinopathy. ...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-03-633933
更新日期:2015-04-23 00:00:00
abstract::Pacritinib (SB1518) is a Janus kinase 2 (JAK2), JAK2(V617F), and Fms-like tyrosine kinase 3 inhibitor that does not inhibit JAK1. It demonstrated a favorable safety profile with promising efficacy in phase 1 studies in patients with primary and secondary myelofibrosis (MF). This multicenter phase 2 study further chara...
journal_title:Blood
pub_type: 杂志文章,多中心研究
doi:10.1182/blood-2013-02-484832
更新日期:2015-04-23 00:00:00
abstract::Sickle cell disease (SCD) is characterized by a single point mutation in the seventh codon of the β-globin gene. Site-specific correction of the sickle mutation in hematopoietic stem cells would allow for permanent production of normal red blood cells. Using zinc-finger nucleases (ZFNs) designed to flank the sickle mu...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-12-615948
更新日期:2015-04-23 00:00:00
abstract::In this issue of Blood, Whyte et al describe how under flow conditions, phosphatidylserine-expressing platelets modulate the lysis of whole blood clots by providing direct and indirect binding sites for plasminogen. ...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-03-632158
更新日期:2015-04-16 00:00:00
abstract::Epigenetic events that are essential drivers of lymphocyte transformation remain incompletely characterized. We used models of Epstein-Barr virus (EBV)-induced B-cell transformation to document the relevance of protein arginine methyltransferase 5 (PRMT5) to regulation of epigenetic-repressive marks during lymphomagen...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-12-619783
更新日期:2015-04-16 00:00:00
abstract::Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-09-599894
更新日期:2015-04-16 00:00:00
abstract::In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating t...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-02-629782
更新日期:2015-04-09 00:00:00
abstract::Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We show that AML blasts constitutively express the arginine transporters ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-09-600643
更新日期:2015-04-09 00:00:00
abstract::Idiopathic pneumonia syndrome (IPS) is a relatively common, frequently fatal clinical entity, characterized by noninfectious acute lung inflammation following allogeneic stem cell transplantation (SCT), the mechanisms of which are unclear. In this study, we demonstrate that immune suppression with cyclosporin after SC...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-07-590232
更新日期:2015-04-09 00:00:00
abstract::We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet generation were recor...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-08-595561
更新日期:2015-04-02 00:00:00
abstract::Mucopolysaccharidosis type I-Hurler syndrome (MPS-IH) is a lysosomal storage disease characterized by multisystem morbidity and death in early childhood. Although hematopoietic cell transplantation (HCT) has been performed in these patients for more than 30 years, large studies on the long-term outcome of patients wit...
journal_title:Blood
pub_type: 杂志文章,多中心研究
doi:10.1182/blood-2014-11-608075
更新日期:2015-03-26 00:00:00
abstract::In multiple myeloma, cytogenetic changes are important predictors of patient outcome. In this setting, the most important changes are deletion 17p, del(17p), and translocation of chromosomes 4 and 14, t(4;14), conferring a poor outcome. However, a certain degree of heterogeneity is observed in the survival of these hi...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-07-587964
更新日期:2015-03-26 00:00:00
abstract::Acute myeloid leukemia (AML) is driven by niche-derived and cell-autonomous stimuli. Although many cell-autonomous disease drivers are known, niche-dependent signaling in the context of the genetic disease heterogeneity has been difficult to investigate. Here, we analyzed the role of Bruton tyrosine kinase (BTK) in AM...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-06-585216
更新日期:2015-03-19 00:00:00
abstract::In this issue of Blood, Savona and an international consortium of clinical investigators propose uniform response criteria for treatment trials enrolling adult patients with myelodysplastic/myeloproliferative neoplasms (MDS/MPNs). Such a proposal is needed because new drugs are finally being tested in these rare “over...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-02-626473
更新日期:2015-03-19 00:00:00
abstract::ADAMTS13 proteolytically regulates the platelet-tethering function of von Willebrand factor (VWF). ADAMTS13 function is dependent upon multiple exosites that specifically bind the unraveled VWF A2 domain and enable proteolysis. We carried out a comprehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich)...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-08-594556
更新日期:2015-03-19 00:00:00
abstract::Immune-mediated platelet destruction is most frequently caused by allo- or autoantibodies via Fcγ receptor-dependent phagocytosis. Disease severity can be predicted neither by antibody isotype nor by titer, indicating that other factors play a role. Here we show that the acute phase protein C-reactive protein (CRP), a...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-05-579110
更新日期:2015-03-12 00:00:00
abstract::We have shown that human B-cell non-Hodgkin lymphomas (B-NHLs) express heat shock protein (HSP)H1/105 in function of their aggressiveness. Here, we now clarify its role as a functional B-NHL target by testing the hypothesis that it promotes the stabilization of key lymphoma oncoproteins. HSPH1 silencing in 4 models of...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-07-590034
更新日期:2015-03-12 00:00:00
abstract::Emerging successful clinical data on gene therapy using adeno-associated viral (AAV) vector for hemophilia B (HB) showed that the risk of cellular immune response to vector capsid is clearly dose dependent. To decrease the vector dose, we explored AAV-8 (1-3 × 10(12) vg/kg) encoding a hyperfunctional factor IX (FIX-Pa...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-07-588194
更新日期:2015-03-05 00:00:00
abstract::In this issue of Blood, Vérollet et al show that expression of the HIV-1–derived protein Nef alters the migratory mode adopted by macrophages, enhancing macrophage tissue infiltration and explaining the observed accumulation of tissue-resident macrophages in some HIV-infected patients. ...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-01-618983
更新日期:2015-03-05 00:00:00
abstract::Macrophages are motile leukocytes, targeted by HIV-1, thought to play a critical role in host dissemination of the virus. However, whether infection impacts their migration capacity remains unknown. We show that 2-dimensional migration and the 3-dimensional (3D) amoeboid migration mode of HIV-1-infected human monocyte...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-08-596775
更新日期:2015-03-05 00:00:00
abstract::Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is initiated and driven by the oncogenic fusion protein BCR-ABL, a constitutively active tyrosine kinase. Despite major advances in the treatment of this highly aggressive disease with potent inhibitors of the BCR-ABL kinase such as dasatinib, pat...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-09-601062
更新日期:2015-02-26 00:00:00
abstract::Although most investigators are well aware of the incredible success of brentuximab vedotin in the treatment of patients with Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL), the study by Jacobsen and colleagues in this issue of Blood demonstrates surprising activity of this agent in patients with B-ce...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2015-01-622480
更新日期:2015-02-26 00:00:00
abstract::Plasmodium vivax merozoites only invade reticulocytes, a minor though heterogeneous population of red blood cell precursors that can be graded by levels of transferrin receptor (CD71) expression. The development of a protocol that allows sorting reticulocytes into defined developmental stages and a robust ex vivo P vi...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-08-596015
更新日期:2015-02-19 00:00:00
abstract::PAX5-JAK2 has recently been identified as a novel recurrent fusion gene in B-cell precursor acute lymphoblastic leukemia, but the function of the encoded chimeric protein has not yet been characterized in detail. Herein we show that the PAX5-JAK2 chimera, which consists of the DNA-binding paired domain of PAX5 and the...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-04-570960
更新日期:2015-02-19 00:00:00